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Ribociclib
| Product Name: | Ribociclib |
| Synonyms: | LEE011;CDK4/6 inhibitor;CDK4 inhibitor;CDK4-IN-1;CS-842;4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-yl)pyrimidin-2-amine;CDK 4/6 Inhibitor, >=98% |
| CAS: | 1256963-02-6 |
| MF: | C22H29ClN8 |
| MW: | 440.97 |
| Product Categories: | Small molecule inhibitor; Pharmaceutical raw materials; Small molecule inhibitors, natural products; Cell biological reagents; Active pharmaceutical ingredients. Inhibitors |
| Application | Ribociclib is an inhibitor of cyclin-dependentkinases4/6 (CDK4/6). These kinases bind to cellular D-cyclin proteins to form active complexes, It plays a key role in the signaling pathways regulating cell cycle progression and cell proliferation.
Ribociclib is indicated for use in combination with an aromatase inhibitor as initial endocrine therapy in postmenopausal women with HR + positive, HER2 advanced or metastatic breast cancer. |
| Ribociclib Chemical Properties | |
| Melting point | >180°C (dec.) |
| Boiling point | 679.3±65.0 °C(Predicted) |
| Density | 1.31±0.1 g/cm3(Predicted) |
| pKa | 7.57±0.50(Predicted) |
| Storage condition | -20°C Freezer |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Powder. |
| color | White |
Product Delivery
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